021-51111890
购物车（）
sales@molnova.cn
Ecteinascidin 770
CAS No. 114899-80-8
Ecteinascidin 770 ( Ecteinascidine 770 | Et 770 | Et-770 | Et770 )
产品货号. M10526 CAS No. 114899-80-8
具有有效抗癌活性的四氢异喹啉生物碱；显示对人细胞系 HCT116、QG56 和 DU145 的细胞毒性，IC50 分别为 0.60、2.4 和 0.81 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥12458 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Ecteinascidin 770
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述具有有效抗癌活性的四氢异喹啉生物碱；显示对人细胞系 HCT116、QG56 和 DU145 的细胞毒性，IC50 分别为 0.60、2.4 和 0.81 nM。
-
产品描述A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.
-
体外实验Ecteinascidin 770 induces apoptosis of U373MG cells. The IC50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment. The IC50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells.
-
体内实验——
-
同义词Ecteinascidine 770 | Et 770 | Et-770 | Et770
-
通路Apoptosis
-
靶点Apoptosis
-
受体Apoptosis
-
研究领域——
-
适应症——
化学信息
-
CAS Number114899-80-8
-
分子量770.84728
-
分子式C40H42N4O10S
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESCC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)C#N)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
-
化学全称Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.
2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.
3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
产品手册
关联产品
-
Lupiwighteone
Lupiwighteone 具有抗血管生成潜力，对 SH-SY5Y 细胞也具有抗癌和预防癌症的作用。
-
TJ191
TJ191是一种选择性抗癌化合物，针对低TβRIII表达的恶性T细胞白血病/淋巴瘤细胞。
-
Mitoguazone
Mitoguazone(Methylglyoxal-bis(guanylhydrazone)) 是一种具有有效抗肿瘤活性的合成多羰基衍生物。Mitoguazone 是一种可透过血脑屏障的竞争性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 诱导细胞凋亡 (apoptosis)，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中。Mitoguazone 具可用于急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤的研究。
