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首页- Products - Apoptosis - Apoptosis - Ecteinascidin 770

Ecteinascidin 770

CAS No. 114899-80-8

Ecteinascidin 770 ( Ecteinascidine 770 | Et 770 | Et-770 | Et770 )

产品货号. M10526 CAS No. 114899-80-8

具有有效抗癌活性的四氢异喹啉生物碱；显示对人细胞系 HCT116、QG56 和 DU145 的细胞毒性，IC50 分别为 0.60、2.4 和 0.81 nM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ￥12458 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Ecteinascidin 770
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    具有有效抗癌活性的四氢异喹啉生物碱；显示对人细胞系 HCT116、QG56 和 DU145 的细胞毒性，IC50 分别为 0.60、2.4 和 0.81 nM。
  • 产品描述
    A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.
  • 体外实验
    Ecteinascidin 770 induces apoptosis of U373MG cells. The IC50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment. The IC50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells.
  • 体内实验
    ——
  • 同义词
    Ecteinascidine 770 | Et 770 | Et-770 | Et770
  • 通路
    Apoptosis
  • 靶点
    Apoptosis
  • 受体
    Apoptosis
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    114899-80-8
  • 分子量
    770.84728
  • 分子式
    C40H42N4O10S
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)C#N)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
  • 化学全称
    Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36. 2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12. 3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
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