021-51111890
购物车（）
sales@molnova.cn
Ecteinascidin 770
CAS No. 114899-80-8
Ecteinascidin 770 ( Ecteinascidine 770;Et 770;Et-770;Et770 )
产品货号. M10526 CAS No. 114899-80-8
A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥12458 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Ecteinascidin 770
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively.
-
产品描述A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.
-
同义词Ecteinascidine 770;Et 770;Et-770;Et770
-
通路Apoptosis
-
靶点Apoptosis
-
受体Apoptosis
-
研究领域——
-
适应症——
化学信息
-
CAS Number114899-80-8
-
分子量770.85
-
分子式C40H42N4O10S
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESCC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)C#N)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
-
化学全称Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.
2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.
3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.
3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.
产品手册
关联产品
-
Galgravin
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons.
-
Bromelain
Bromelain is an anti-inflammatory drug derived from pineapple stem.
-
DT2216
DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).
